Sodium Iodide → 2-(4-Methoxyphenyl)-4-iodomethyl-5-methyloxazole

HRID 2233556

Reaktionsgleichung

Reaktionsgleichung von HRID 2233556
[I-:1].[Na+].Cl[CH2:4][C:5]1[N:6]=[C:7]([C:11]2[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=2)[O:8][C:9]=1[CH3:10]>CC(C)=O>[I:1][CH2:4][C:5]1[N:6]=[C:7]([C:11]2[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=2)[O:8][C:9]=1[CH3:10]

Komponenten

4

Edukt 2

HCID 5238Sodium IodideHCID 144799554-(Chloromethyl)-2-(4-methoxyphenyl)-5-methyl-1,3-oxazole

Produkt 1

HCID 224936592-(4-Methoxyphenyl)-4-iodomethyl-5-methyloxazole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

Together with 37.7 g of sodium iodide, 19.9 g of 4-chloromethyl-2-(4-methoxy-phenyl)-5-methyl-oxazole are, in 300 ml of acetone, heated at the boil under reflux for 2 hours. After cooling of the reaction mixture, the solvent was removed under reduced pressure and the residue dissolved in 300 ml of methyl tert-butyl ether, the mixture is washed three times with saturated Na2S2O3 solution and dried over MgSO4, and the solvent is then removed under reduced pressure. This gives 49.8 g of 4-Iodomethyl-2-(4-methoxyphenyl)-5-methyloxazole as a light-brown solid.

Aufarbeitung

  1. temperatureheated at the boil
  2. temperatureunder reflux for 2 hours
  3. temperatureAfter cooling of the reaction mixture
  4. customthe solvent was removed under reduced pressure
  5. dissolutionthe residue dissolved in 300 ml of methyl tert-butyl ether
  6. washthe mixture is washed three times with saturated Na2S2O3 solution
  7. dry with materialdried over MgSO4
  8. customthe solvent is then removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-e918121f953b4191933a6f57c3dc45fc
Quelldatensatz
uspto-grants-2010_05
Patentnummer
US07709509B2

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