1-(4-Chlorophenoxy)acetone → HCID 68617744, Verbindung

HRID 2233741Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2233741
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[NH:11]N.[Cl:13][C:14]1[CH:24]=[CH:23][C:17]([O:18][CH2:19][C:20](=O)[CH3:21])=[CH:16][CH:15]=1>CC#N.O>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[C:4]2[C:3]=1[NH:11][C:20]([CH3:21])=[C:19]2[O:18][C:17]1[CH:16]=[CH:15][C:14]([Cl:13])=[CH:24][CH:23]=1

Komponenten

5

Edukt 2

HCID 2398741-(4-Chlorophenoxy)acetoneHCID 53402499(2-Bromo-5-nitrophenyl)hydrazine

Produkt 1

HCID 68617744HCID 68617744, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 6342AcetonitrileLösungsmittel

Reaktionsbedingungen

Temperatur
75 °C

Versuchsvorschrift

A mixture of the compound from (i) (2.4 g) and 1-(4-Chloro-phenoxy)-propan-2-one (1.65 g) in MeCN (20 ml) and water (5 ml) was stirred for 16 h. The volatiles were removed in vacuo. AcOH (50 ml) was added and the reaction heated at 75° C. for 72 h. The volatiles were evaporated under reduced pressure and the residue was purified by chromatography on silica eluting with 5% ethylacetate/iso-hexane. Yield 0.34 g

Aufarbeitung

  1. customThe volatiles were removed in vacuo
  2. additionAcOH (50 ml) was added
  3. customThe volatiles were evaporated under reduced pressure
  4. customthe residue was purified by chromatography on silica eluting with 5% ethylacetate/iso-hexane

Quellen und Nachweise

ORD-Eintrag
ord-bd892b9f6f3440b48b6590ad1fbadcc5
Quelldatensatz
uspto-grants-2010_05
Patentnummer
US07709521B2

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