Water → 3-(4-Chlorophenoxy)-2-methyl-4-[(methylsulfonyl)amino]-1H-indole-1-acetic acid

HRID 2233745Notizen

Reaktionsgleichung

[OH-].[Na+].[Cl:3][C:4]1[CH:33]=[CH:32][C:7]([O:8][C:9]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][C:16]=3[NH:18][S:19]([CH3:22])(=[O:21])=[O:20])[N:11]([CH2:23][C:24]([O:26]C(C)(C)C)=[O:25])[C:10]=2[CH3:31])=[CH:6][CH:5]=1.O>C1COCC1>[Cl:3][C:4]1[CH:5]=[CH:6][C:7]([O:8][C:9]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][C:16]=3[NH:18][S:19]([CH3:22])(=[O:20])=[O:21])[N:11]([CH2:23][C:24]([OH:26])=[O:25])[C:10]=2[CH3:31])=[CH:32][CH:33]=1

Komponenten

Reaktionsbedingungen

Temperatur: 55 °C

Versuchsvorschrift

A solution of 1M sodium hydroxide (0.5 ml) was added to a stirred mixture of the product from step (v) (40 mg) in THF (1 ml). After 3 h, further 1M sodium hydroxide (1 ml) was added and the reaction heated at 55° C. for 16 h. Water (10 ml) was added and the THF evaporated under reduced pressure. The solution was acidified with 2M hydrochloric acid and the resulting solid filtered off and dried. Yield 24 mg

Aufarbeitung

customthe THF evaporated under reduced pressure
filtrationthe resulting solid filtered off
customdried

Quellen und Nachweise

ORD-Eintrag: ord-933f1f84ed0f47e7becc83c9e33fb5b8
Quelldatensatz: uspto-grants-2010_05
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US07709521B2

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