N-(3-dimethylamino-2,2-dimethyl-propyl)-3-methoxy-4-nitro-benzamide → 4-amino-N-(3-dimethylamino-2,2-dimethyl-propyl)-3-methoxy-benzamide

HRID 2234354Notizen

Reaktionsgleichung

[CH3:1][N:2]([CH3:22])[CH2:3][C:4]([CH3:21])([CH3:20])[CH2:5][NH:6][C:7](=[O:19])[C:8]1[CH:13]=[CH:12][C:11]([N+:14]([O-])=O)=[C:10]([O:17][CH3:18])[CH:9]=1>CCO.[Pd]>[NH2:14][C:11]1[CH:12]=[CH:13][C:8]([C:7]([NH:6][CH2:5][C:4]([CH3:20])([CH3:21])[CH2:3][N:2]([CH3:1])[CH3:22])=[O:19])=[CH:9][C:10]=1[O:17][CH3:18]

Komponenten

Reaktionsbedingungen

Temperatur: 40 °C

Versuchsvorschrift

A suspension of N-(3-dimethylamino-2,2-dimethyl-propyl)-3-methoxy-4-nitro-benzamide (Intermediate 23; 5.7 g, 18.40 mmol), 5% Pd on charcoal (569 mg) in EtOH (300 mL) was stirred at 40° C. under a hydrogen atmosphere for 16 h. The reaction mixture was then filtered through celite, washed with copious MeOH and the volatiles removed under reduced pressure to afford the title compound (5.36 g, Quant.) as a foam.

Aufarbeitung

filtrationThe reaction mixture was then filtered through celite
washwashed with copious MeOH
customthe volatiles removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag: ord-c80c79f728ad48729456c07f8c630038
Quelldatensatz: uspto-grants-2010_05
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US07709471B2

Notizen zur Reaktion

Wird geladen…