Sodium borohydride → 2,3-dibromo-4-hydroxy-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]azepin-8-one

HRID 2234765

Reaktionsgleichung

Reaktionsgleichung von HRID 2234765
[Br:1][C:2]1[NH:13][C:5]2[C:6](=[O:12])[NH:7][CH2:8][CH2:9][C:10](=[O:11])[C:4]=2[C:3]=1[Br:14].[BH4-].[Na+]>CN(C=O)C.CO>[Br:1][C:2]1[NH:13][C:5]2[C:6](=[O:12])[NH:7][CH2:8][CH2:9][CH:10]([OH:11])[C:4]=2[C:3]=1[Br:14]

Komponenten

4

Edukt 2

HCID 4311764Sodium borohydrideHCID 686372062,3-dibromo-6,7-dihydro-1H,5H-pyrrolo[2,3-c]azepine-4,8-dione

Produkt 1

HCID 597892072,3-dibromo-4-hydroxy-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]azepin-8-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 21901440N,N-dimethylformamide methanolLösungsmittel

Versuchsvorschrift

To a solution of 2,3-dibromo-6,7-dihydro-1H,5H-pyrrolo[2,3-c]azepine-4,8-dione (2.5 g, 7.74 mmol) in a mixture of DMF-MeOH (6 mL) is added NaBH4 (1.47 g, 38.7 mmol). The mixture is stirred at room temperature overnight. It is concentrated and water is added. The mixture is extracted with EtOAc, washed with brine and dried. After the solvent is removed, the residue is subjected to silica gel column chromatography and eluted with CH2Cl2-MeOH to give 2,3-dibromo-4-hydroxy-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]azepin-8-one; 1H NMR (DMSO-d6) δ 1.74-1.84 (m, 1H), 2.01-2.10 (m, 1H), 3.00-3.10 (m, 1H), 3.42-3.50 (m, 1H), 4.63-4.68 (m, 1H), 5.06 (d, 1H, J=6.4 Hz), 7.92 (d, 1H, J=4.4 Hz); m/z [M++1] 324.9.

Aufarbeitung

  1. concentrationIt is concentrated
  2. additionwater is added
  3. extractionThe mixture is extracted with EtOAc
  4. washwashed with brine
  5. customdried
  6. customAfter the solvent is removed
  7. washeluted with CH2Cl2-MeOH

Quellen und Nachweise

ORD-Eintrag
ord-d06a9a082651470d9463d6f8a782abb2
Quelldatensatz
uspto-grants-2010_05
Patentnummer
US07713958B2

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