(1-Phenyl-cyclohexyl)-carbamic acid benzyl ester → 1-Phenylcyclohexylamine

HRID 2235199Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2235199
C(OC(=O)[NH:10][C:11]1([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1)C1C=CC=CC=1>CO.[Pd]>[C:17]1([C:11]2([NH2:10])[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]2)[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

Komponenten

4

Edukt 1

HCID 59299316(1-Phenyl-cyclohexyl)-carbamic acid benzyl ester

Produkt 1

HCID 318621-PhenylcyclohexylamineAusbeute 90,4 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

Dissolve (1-phenyl-cyclohexyl)-carbamic acid benzyl ester (Preparation 27) (2.87 g, 9.26 mmol) in MeOH (100 mL). Exchange air with nitrogen for three times and then add Pd—C (0.5 g, 10%). Exchange the nitrogen with H2 for three times. Stir the reaction mixture under H2 for over night then remove the Pd—C by filtration. Remove the solvent under reduced pressure to give 1.468 g (90%) of the crude title compound as a colorless oil.

Aufarbeitung

  1. customthen remove the Pd—C
  2. filtrationby filtration
  3. customRemove the solvent under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-658ad1920c5349a7aedaee767557cf7c
Quelldatensatz
uspto-grants-2010_05
Patentnummer
US07713979B2

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