5-Isopropylamino-3,3-dimethyl-6-nitro-1-pentyl-1,3-dihydro-indol-2-one → 6-Amino-5-isopropylamino-3,3-dimethyl-1-pentyl-1,3-dihydro-indol-2-one

HRID 2235459Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2235459
[CH:1]([NH:4][C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][C:13]=1[N+:14]([O-])=O)[N:10]([CH2:17][CH2:18][CH2:19][CH2:20][CH3:21])[C:9](=[O:22])[C:8]2([CH3:24])[CH3:23])([CH3:3])[CH3:2]>CN(C)C=O.[Pd]>[NH2:14][C:13]1[CH:12]=[C:11]2[C:7]([C:8]([CH3:24])([CH3:23])[C:9](=[O:22])[N:10]2[CH2:17][CH2:18][CH2:19][CH2:20][CH3:21])=[CH:6][C:5]=1[NH:4][CH:1]([CH3:2])[CH3:3]

Komponenten

4

Edukt 1

HCID 674274925-Isopropylamino-3,3-dimethyl-6-nitro-1-pentyl-1,3-dihydro-indol-2-one

Produkt 1

HCID 674272526-Amino-5-isopropylamino-3,3-dimethyl-1-pentyl-1,3-dihydro-indol-2-oneAusbeute 98,9 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

5-Isopropylamino-3,3-dimethyl-6-nitro-1-pentyl-1,3-dihydro-indol-2-one (200 mg) is dissolved in N,N-dimethylformamide (10 ml) and hydrogenated at RT at 3 bar for 12 h using Pd/C (10%; 0.1 g) as catalyst. After completion of the reaction the mixture is filtered and evaporated to give the compound (180 mg).

Aufarbeitung

  1. customAfter completion of the reaction the mixture
  2. filtrationis filtered
  3. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-683e9cf6a17f4091985f8279a337732a
Quelldatensatz
uspto-grants-2010_05
Patentnummer
US07714010B2

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