Hydrochloric Acid → 3-Fluoro-4-MethoxybenzylaMineHCl

HRID 2236657Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2236657
CO[N:3]=[CH:4][C:5]1[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[C:7]([F:13])[CH:6]=1.[ClH:14]>C(O)C.[Pd]>[ClH:14].[F:13][C:7]1[CH:6]=[C:5]([CH:10]=[CH:9][C:8]=1[O:11][CH3:12])[CH2:4][NH2:3]

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 87542948HCID 87542948, Verbindung

Produkt 1

HCID 224674033-Fluoro-4-MethoxybenzylaMineHCl

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

To a solution of 3-fluoro-4-methoxy-benzaldehyde O-methyl-oxime (0.60 g, 3.3 mmol) in ethanol (25 mL) is added concentrated ethanolic hydrogen chloride (2 mL) and palladium on carbon (10%, 250 mg). The suspension is hydrogenated at atmospheric pressure for 18 hours, then filtered through diatomaceous earth and finally concentrated to give 3-fluoro-4-methoxy-benzylamine hydrochloride as a white solid.

Aufarbeitung

  1. filtrationfiltered through diatomaceous earth
  2. concentrationfinally concentrated

Quellen und Nachweise

ORD-Eintrag
ord-4749d880f44b4308984218dbc2650049
Quelldatensatz
uspto-grants-2010_05
Patentnummer
US07713994B2

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