4-(Dibenzofuran-2-yloxy)-1-nitrobenzene → 4-(Dibenzofuran-2-yloxy)aniline

HRID 2237041

Reaktionsgleichung

Reaktionsgleichung von HRID 2237041
[CH:1]1[C:9]2[C:8]3[CH:10]=[CH:11][CH:12]=[CH:13][C:7]=3[O:6][C:5]=2[CH:4]=[CH:3][C:2]=1[O:14][C:15]1[CH:20]=[CH:19][C:18]([N+:21]([O-])=O)=[CH:17][CH:16]=1>CCOC(C)=O.[Pd]>[CH:1]1[C:9]2[C:8]3[CH:10]=[CH:11][CH:12]=[CH:13][C:7]=3[O:6][C:5]=2[CH:4]=[CH:3][C:2]=1[O:14][C:15]1[CH:20]=[CH:19][C:18]([NH2:21])=[CH:17][CH:16]=1

Komponenten

4

Edukt 1

HCID 21028934-(Dibenzofuran-2-yloxy)-1-nitrobenzene

Produkt 1

HCID 669774564-(Dibenzofuran-2-yloxy)aniline

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

The nitro intermediate (10 mmol) obtained above was dissolved in EtOAc (50 mL) and hydrogenated in the presence of 10% Pd/C (360 mg) until completion according to General Procedure H, as indicated by TLC or HPLC. The reaction mixture was then filtered to remove the catalyst. The solvent was removed in vacuuo to afford the desired 4-(dibenzofuran-2-yloxy)aniline, which was used directly for further transformation without further purification.

Aufarbeitung

  1. filtrationThe reaction mixture was then filtered
  2. customto remove the catalyst
  3. customThe solvent was removed in vacuuo

Quellen und Nachweise

ORD-Eintrag
ord-050c5ff6f9484d32988a6bd745acfd9d
Quelldatensatz
uspto-grants-2010_05
Patentnummer
US07714013B2

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