Dimethylformamide → Dibenzyl 4-chloro-3,3-dimethyl-4-oxobutyl phosphate

HRID 2238333Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2238333
[CH2:1]([O:8][P:9]([O:19][CH2:20][CH2:21][C:22]([CH3:27])([CH3:26])[C:23](O)=[O:24])([O:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.CN(C=O)C.C(Cl)(=O)C([Cl:36])=O>ClCCl>[P:9]([O:19][CH2:20][CH2:21][C:22]([CH3:27])([CH3:26])[C:23]([Cl:36])=[O:24])([O:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)([O:8][CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)=[O:10]

Komponenten

5

Edukt 3

HCID 6228DimethylformamideHCID 65578Oxalyl chlorideHCID 672351544-{[Bis(benzyloxy)phosphoryl]oxy}-2,2-dimethylbutanoic acid

Produkt 1

HCID 86616512Dibenzyl 4-chloro-3,3-dimethyl-4-oxobutyl phosphate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel2×

Versuchsvorschrift

To a solution of the product from Example 11B (0.211 g, 0.538 mmol) in dichloromethane (1.35 mL) at 0° C. were added DMF (4 μL) and a solution of oxalyl chloride in dichloromethane (2M, 0.538 mL) and the mixture was stirred for 45 minutes at 0° C. The solvent was evaporated under reduced pressure and the residue was used without further purification.

Aufarbeitung

  1. customThe solvent was evaporated under reduced pressure
  2. customthe residue was used without further purification

Quellen und Nachweise

ORD-Eintrag
ord-4a3dce8c594e44f89019041f54d6526c
Quelldatensatz
uspto-grants-2010_05
Patentnummer
US07718633B2

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