Triethylamine → HCID 86611739, Verbindung

HRID 2239860

Reaktionsgleichung

[CH3:1][CH2:2][O:3][C:4]1[CH:5]=[CH:6][C:7]([NH2:10])=[CH:8][CH:9]=1.C(N(CC)CC)C.[Br:18][C:19]1[N:23]2[N:24]=[C:25]([Cl:29])[CH:26]=[C:27](Br)[C:22]2=[N:21][CH:20]=1>CCO>[Br:18][C:19]1[N:23]2[N:24]=[C:25]([Cl:29])[CH:26]=[C:27]([NH:10][C:7]3[CH:8]=[CH:9][C:4]([O:3][CH2:2][CH3:1])=[CH:5][CH:6]=3)[C:22]2=[N:21][CH:20]=1

Komponenten

Reaktionsbedingungen

Temperatur: 80 °C

Versuchsvorschrift

p-Phenetidine (0.38 ml, 2.9 mmol) and triethylamine (0.8 ml, 5.8 mmol) were added to a mixture of 3,8-dibromo-6-chloroimidazo[1,2-b]pyridazine (0.83 g, 2.67 mmol) from 1a in EtOH (10 mL). The mixture was heated to 80° C. and stirred for 16 hrs. The solution was then concentrated in vacuo to give crude 3-bromo-6-chloro-N-(4-ethoxyphenyl)imidazo[1,2-b]pyridazin-8-amine.

Aufarbeitung

concentrationThe solution was then concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag: ord-22aefa9687de43a08b620f0d46b1c95b
Quelldatensatz: uspto-grants-2010_05
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US07723336B2

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