Propylamine → (2-Chloro-6,7-dihydrothieno[3,2-d]pyrimidin-4-yl)propylamine

HRID 2240103Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2240103
[Cl:1][C:2]1[N:3]=[C:4](Cl)[C:5]2[S:10][CH:9]=[CH:8][C:6]=2[N:7]=1.[CH2:12]([NH2:15])[CH2:13][CH3:14].C(N(C(C)C)C(C)C)C>O1CCCC1>[Cl:1][C:2]1[N:3]=[C:4]([CH2:14][CH2:13][CH2:12][NH2:15])[C:5]2[S:10][CH2:9][CH2:8][C:6]=2[N:7]=1

Komponenten

5

Edukt 3

HCID 7852PropylamineHCID 81531DiisopropylethylamineHCID 127128322,4-Dichlorothieno[3,2-d]pyrimidine

Produkt 1

HCID 86632801(2-Chloro-6,7-dihydrothieno[3,2-d]pyrimidin-4-yl)propylamineAusbeute 86,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

10.4 g (50.2 mmol) of 2,4-dichlorothieno[3,2-d]pyrimidine (VII), 8.2 mL (100 mmol) of N-propylamine, and 17.5 mL (100 mmol) of N-ethyldiisopropylamine are placed in 100 mL of tetrahydrofuran and stirred for 20 hours at ambient temperature. The suspension is filtered, the filtrate is concentrated by evaporation. The residue is combined with 100 mL of water and treated in the ultrasound bath. Solid substance is suction filtered, dried, and stirred with 50 mL of petroleum ether. 10.0 g of the product VIII (86%) is obtained as a powder.

Aufarbeitung

  1. filtrationThe suspension is filtered
  2. concentrationthe filtrate is concentrated by evaporation
  3. additiontreated in the ultrasound bath
  4. filtrationfiltered
  5. customdried
  6. stirringstirred with 50 mL of petroleum ether

Quellen und Nachweise

ORD-Eintrag
ord-6c1fd959957f44878831389120605ad9
Quelldatensatz
uspto-grants-2010_05
Patentnummer
US07723341B2

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