Water → HCID 59305034, Verbindung

HRID 2240253Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2240253
[OH-].[Na+].[F:3][C:4]1[C:12]2[C:11]([NH:13][C:14]3[CH:19]=[CH:18][C:17]([N+:20]([O-:22])=[O:21])=[CH:16][C:15]=3[F:23])=[CH:10][CH:9]=[N:8][C:7]=2[N:6](S(C2C=CC(C)=CC=2)(=O)=O)[CH:5]=1.O.C(OCC)(=O)C>C(O)C>[F:3][C:4]1[C:12]2[C:11]([NH:13][C:14]3[CH:19]=[CH:18][C:17]([N+:20]([O-:22])=[O:21])=[CH:16][C:15]=3[F:23])=[CH:10][CH:9]=[N:8][C:7]=2[NH:6][CH:5]=1

Komponenten

6

Edukt 4

HCID 962WaterHCID 8857Ethyl AcetateHCID 14798Sodium HydroxideHCID 59304991HCID 59304991, Verbindung

Produkt 1

HCID 59305034HCID 59305034, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

0.4 ml of a 20% strength aqueous sodium hydroxide solution is added to a solution of 80 mg (0.18 mmol) of 3-fluoro-N-(2-fluoro-4-nitrophenyl)-1-[(4-methylphenyl)-sulfonyl]-1H-pyrrolo[2,3-b]pyridine-4-amine in 5 ml of ethanol, and the mixture is stirred overnight. The reaction solution is then poured into a mixture of water and ethyl acetate, and the aqueous phase is extracted two more times with ethyl acetate. Purification by preparative HPLC gives the target compound.

Aufarbeitung

  1. extractionthe aqueous phase is extracted two more times with ethyl acetate
  2. customPurification by preparative HPLC
  3. customgives the target compound

Quellen und Nachweise

ORD-Eintrag
ord-74da6de7d8484f7ab9e285fae406a443
Quelldatensatz
uspto-grants-2010_05
Patentnummer
US07723347B2

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