Triethylamine → 2-Bromo-N-(5-methyl-isoxazol-3-yl)-acetamide

HRID 2240292Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2240292
[CH3:1][C:2]1[O:6][N:5]=[C:4]([NH2:7])[CH:3]=1.C(N(CC)CC)C.[Br:15][CH2:16][C:17](Br)=[O:18]>C(Cl)(Cl)Cl>[Br:15][CH2:16][C:17]([NH:7][C:4]1[CH:3]=[C:2]([CH3:1])[O:6][N:5]=1)=[O:18]

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 61147Bromoacetyl bromideHCID 661723-Amino-5-methylisoxazole

Produkt 1

HCID 64850652-Bromo-N-(5-methyl-isoxazol-3-yl)-acetamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel2×

Reaktionsbedingungen

Temperatur
-40 °C

Versuchsvorschrift

To a stirred solution of 5-methyl-isoxazol-3-ylamine (4.0 g, 40.8 mmol) and triethylamine (6.8 ml, 50 mmol) in chloroform (20 ml) cooled to −40° C., is added bromoacetyl bromide (3.9 ml, 44.9 mmol) in chloroform (20 ml). The reaction mixture is stirred at −40° C. for 30 minutes and then allowed to warm to room temperature. The resultant suspension is filtered, washed with DCM and dried in vacuo to yield the titled compound.

Aufarbeitung

  1. temperatureto warm to room temperature
  2. filtrationThe resultant suspension is filtered
  3. washwashed with DCM
  4. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-e1cfa6179eae4288a4def748a48c1cf0
Quelldatensatz
uspto-grants-2010_05
Patentnummer
US07723356B2

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