2-Fluoro-5-iodotoluene → 4-(4-Difluoromethoxy-phenylethynyl)-1-fluoro-2-methyl-benzene

HRID 2240939

Reaktionsgleichung

Reaktionsgleichung von HRID 2240939
[F:1][C:2]1[CH:7]=[CH:6][C:5](I)=[CH:4][C:3]=1[CH3:9].[F:10][CH:11]([F:21])[O:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]#[CH:20])=[CH:15][CH:14]=1>>[F:10][CH:11]([F:21])[O:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]#[C:20][C:5]2[CH:6]=[CH:7][C:2]([F:1])=[C:3]([CH3:9])[CH:4]=2)=[CH:15][CH:14]=1

Komponenten

3

Edukt 2

HCID 5211782-Fluoro-5-iodotolueneHCID 27784971-(Difluoromethoxy)-4-ethynylbenzene

Produkt 1

HCID 593053114-(4-Difluoromethoxy-phenylethynyl)-1-fluoro-2-methyl-benzene

Versuchsvorschrift

The title compound was prepared in substantially the same manner as described in Example 12, step 3 starting from 1-Fluoro-4-iodo-2-methyl-benzene (0.125 g, 0.53 mmol), and 1-Difluoromethoxy-4-ethynyl-benzene (0.09 g, 0.53 mmol), and was obtained as a yellow semi solid, (0.141 g, 96%), and identified by NMR and mass spectral analyses. MS (EI+): 276 (M+).

Aufarbeitung

  1. customwas obtained as a yellow semi solid, (0.141 g, 96%),

Quellen und Nachweise

ORD-Eintrag
ord-b5849fc4cf3a417f8b6172df3497d72b
Quelldatensatz
uspto-grants-2010_05
Patentnummer
US07723368B2

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