4-(4-Nitro-2-(trifluoromethyl)phenyl)morpholine → 4-Morpholino-3-(trifluoromethyl)aniline

HRID 2241911

Reaktionsgleichung

Reaktionsgleichung von HRID 2241911
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:15][CH2:14][O:13][CH2:12][CH2:11]2)=[C:6]([C:16]([F:19])([F:18])[F:17])[CH:5]=1)([O-])=O>[Pt](=O)=O.CO>[O:13]1[CH2:12][CH2:11][N:10]([C:7]2[CH:8]=[CH:9][C:4]([NH2:1])=[CH:5][C:6]=2[C:16]([F:18])([F:19])[F:17])[CH2:15][CH2:14]1

Komponenten

4

Edukt 1

HCID 6128564-(4-Nitro-2-(trifluoromethyl)phenyl)morpholine

Produkt 1

HCID 27713294-Morpholino-3-(trifluoromethyl)anilineAusbeute 58 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 345198Adams' catalystKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of 4-[4-nitro-2-(trifluoromethyl)phenyl]morpholine (compound of Reference Example 2; 1.20 g, 4.344 mmol), platinum(IV) oxide (0.10 g) and methanol (12 ml) was stirred at room temperature for 12.5 hours under hydrogen atmosphere. The reaction mixture was filtered and the residue obtained by evaporation of the solvent of the filtrate under reduced pressure was washed with n-hexane to give the title compound (0.62 g, 58%) as a colorless crystal.

Aufarbeitung

  1. filtrationThe reaction mixture was filtered
  2. customthe residue obtained by evaporation of the solvent of the filtrate under reduced pressure
  3. washwas washed with n-hexane

Quellen und Nachweise

ORD-Eintrag
ord-94bc5a01980a45948f8fcd0f231bdc88
Quelldatensatz
uspto-grants-2010_03
Patentnummer
US07671058B2

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