[CH2:1]([C:5]1[CH:13]=[CH:12][CH:11]=[CH:10][C:6]=1C(O)=O)[CH:2]([CH3:4])[CH3:3].CN([C:17]([O:21]N1N=NC2C=CC=CC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.C(N(C(C)C)CC)(C)C.[NH2:47][NH2:48]>CN(C=O)C.C(OCC)(=O)C>[CH2:1]([C:5]1[CH:6]=[CH:10][C:11]([C:17]([NH:47][NH2:48])=[O:21])=[CH:12][CH:13]=1)[CH:2]([CH3:3])[CH3:4]A solution isobutylbenzoic acid (2.00 g, 11.2 mmol) in DMF (10 ml) was treated with HBTU (4.25 g, 11.2 mmol), diisopropylethylamine (7.24 g, 56.0 mmol), then hydrazine (1.80 g, 56.0 mmol) and stirred at room temperature for 12 hours. The reaction was diluted with ethyl acetate (150 mL), washed with 5% NaHCO3 (aq.) and brine, dried (MgSO4), filtered and concentrated in vacuo to give the title compound (2.10 g, 91%) as a white solid.
Wird geladen…
