Hydroxyamine hydrochloride → N'-hydroxy-3-(hydroxymethyl)benzimidamide

HRID 2242245Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2242245
Cl.[OH:2][NH2:3].C(=O)(O)[O-].[Na+].[OH:9][CH2:10][C:11]1[CH:12]=[C:13]([CH:16]=[CH:17][CH:18]=1)[C:14]#[N:15]>CO>[OH:2][N:3]=[C:14]([C:13]1[CH:16]=[CH:17][CH:18]=[C:11]([CH2:10][OH:9])[CH:12]=1)[NH2:15]

Komponenten

5

Edukt 3

HCID 443297Hydroxyamine hydrochlorideHCID 516892Sodium BicarbonateHCID 27346773-(Hydroxymethyl)benzonitrile

Produkt 1

HCID 74865044N'-hydroxy-3-(hydroxymethyl)benzimidamideAusbeute 105,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

Hydroxyl amine hydrochloride (2.29 g, 32.9 mmol) and sodium bicarbonate (5.52 g, 65.8 mmol) were added to 3-(hydroxymethyl)benzonitrile (2.19 g, 16.4 mmol) and methanol (30 mL) and stirred at reflux for 18 hours. The reaction mixture was cooled to ambient temperature and filtered. The filtrate was concentrated in vacuo to give the title compound (2.88 g, 100% yield) as a solid.

Aufarbeitung

  1. temperatureat reflux for 18 hours
  2. filtrationfiltered
  3. concentrationThe filtrate was concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-50dca5ceb82844329cd1beb4a8475d8a
Quelldatensatz
uspto-grants-2010_03
Patentnummer
US07671043B2

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