HCID 10999447, Verbindung → 2-Phenylquinolin-6-amine

HRID 2243082Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2243082
[C:1]1([C:7]2[CH:16]=[CH:15][C:14]3[C:9](=[CH:10][CH:11]=[C:12]([N+:17]([O-])=O)[CH:13]=3)[N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>C1COCC1.CO.[Pd]>[C:1]1([C:7]2[CH:16]=[CH:15][C:14]3[C:9](=[CH:10][CH:11]=[C:12]([NH2:17])[CH:13]=3)[N:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Komponenten

5

Edukt 1

HCID 10999447HCID 10999447, Verbindung

Produkt 1

HCID 171481752-Phenylquinolin-6-amine

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

Pd/C (10%; 0.60 g) is added to 2-phenyl-6-nitroquinoline (7 g, 0.028 mol) in THF (300 ml) and methanol (300 ml). The mixture is hydrogenated at room temperature and at 1 atm. The catalyst is filtered off, the filtrate is evaporated and the product is recrystallized from isopropyl ether. Yield: 5.7 g (92%); Rf (9/1 chloroform/methanol): 0.56; IR (KBr): 3455, 3320, 3205, 1625, 1495 cm−1.

Aufarbeitung

  1. customis hydrogenated at room temperature and at 1 atm
  2. filtrationThe catalyst is filtered off
  3. customthe filtrate is evaporated
  4. customthe product is recrystallized from isopropyl ether

Quellen und Nachweise

ORD-Eintrag
ord-30c50a19a791453b89a8ecac714bc420
Quelldatensatz
uspto-grants-2010_03
Patentnummer
US07674809B2

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