Glutaric anhydride → 4-[(4-Ethynylphenyl)carbamoyl]butanoic acid

HRID 2243456

Reaktionsgleichung

Reaktionsgleichung von HRID 2243456
[C:1]([C:3]1[CH:9]=[CH:8][C:6]([NH2:7])=[CH:5][CH:4]=1)#[CH:2].[C:10]1(=[O:17])[O:16][C:14](=[O:15])[CH2:13][CH2:12][CH2:11]1>C(Cl)Cl>[C:1]([C:3]1[CH:9]=[CH:8][C:6]([NH:7][C:10](=[O:17])[CH2:11][CH2:12][CH2:13][C:14]([OH:16])=[O:15])=[CH:5][CH:4]=1)#[CH:2]

Komponenten

4

Edukt 2

HCID 7940Glutaric anhydrideHCID 37600254-Ethynylaniline

Produkt 1

HCID 248264774-[(4-Ethynylphenyl)carbamoyl]butanoic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of 4-ethynylaniline (0.99 g, 8.5 mmol) in CH2Cl2 (100 ml) is added glutaric anhydride (1.06 g, 9.30 mmol). After 1 h, the resulting slurry is concentrated by rotary evaporation and the crude mixture is purified by silica column chromatography (10% methanol/5% TEA/CH2Cl2).

Aufarbeitung

  1. concentrationthe resulting slurry is concentrated by rotary evaporation
  2. customthe crude mixture is purified by silica column chromatography (10% methanol/5% TEA/CH2Cl2)

Quellen und Nachweise

ORD-Eintrag
ord-98518cd5c54c4e6c97898ba1c6732705
Quelldatensatz
uspto-grants-2010_03
Patentnummer
US07674924B2

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