Hydrazine hydrate (1:1) → 1-Methyl-2-oxo-1,2-dihydropyridine-4-carbohydrazide

HRID 2243889Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2243889
C[O:2][C:3]([C:5]1[CH:10]=[CH:9][N:8]([CH3:11])[C:7](=[O:12])[CH:6]=1)=O.O.[NH2:14][NH2:15]>C(O)C>[CH3:11][N:8]1[CH:9]=[CH:10][C:5]([C:3]([NH:14][NH2:15])=[O:2])=[CH:6][C:7]1=[O:12]

Komponenten

4

Edukt 2

HCID 24654Hydrazine hydrate (1:1)HCID 819408Methyl 1-methyl-2-oxo-1,2-dihydropyridine-4-carboxylate

Produkt 1

HCID 431322131-Methyl-2-oxo-1,2-dihydropyridine-4-carbohydrazideAusbeute 78,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
78 °C

Versuchsvorschrift

The title compound of example 24 (4.0 g, 23.9 mmol) was dissolved in ethanol (50 mL). Hydrazine hydrate (5.8 mL, 119 mmol) was added and the reaction was stirred at 78° C. for 3 hours. The reaction mixture was then cooled to room temperature and the product was filtered off to give 3.13 g (78% yield) of the title compound as a light yellow solid.

Aufarbeitung

  1. temperatureThe reaction mixture was then cooled to room temperature
  2. filtrationthe product was filtered off

Quellen und Nachweise

ORD-Eintrag
ord-6e985cf53a5940caab4753b815de760d
Quelldatensatz
uspto-grants-2010_03
Patentnummer
US07678796B2

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