Hydrazine hydrate (1:1) → (1S,8R)-5-(1-tert-Butyl-5-trifluoromethyl-1H-pyrazol-4-yl)-1,11,11-trimethyl-3,4-diaza-tricyclo[6.2.1.02,7]undeca-2,4,6-triene
Reaktionsgleichung
[CH3:1][C:2]12[C:8]([CH3:10])([CH3:9])[CH:5]([CH2:6][CH2:7]1)[C:4](=O)[C:3]2=O.COP([CH2:19][C:20]([C:22]1[CH:23]=[N:24][N:25]([C:31]([CH3:34])([CH3:33])[CH3:32])[C:26]=1[C:27]([F:30])([F:29])[F:28])=O)(=O)OC.O.[NH2:36][NH2:37]>>[C:31]([N:25]1[C:26]([C:27]([F:30])([F:29])[F:28])=[C:22]([C:20]2[CH:19]=[C:4]3[C:3]([C@:2]4([CH3:1])[C:8]([CH3:10])([CH3:9])[C@H:5]3[CH2:6][CH2:7]4)=[N:37][N:36]=2)[CH:23]=[N:24]1)([CH3:34])([CH3:33])[CH3:32]Komponenten
4
Edukt 3
Produkt 1
Versuchsvorschrift
yellow solid. MS (ESI): 379.2 (MH+). Prepared from 1,7,7-trimethyl-bicyclo[2.2.1]heptane-2,3-dione, [2-(1-tert-Butyl-5-trifluoromethyl-1H-pyrazol-4-yl)-2-oxo-ethyl]-phosphonic acid dimethyl ester, hydrazine monohydrate.