N,N-Dimethylaniline → HCID 9799174, Verbindung

HRID 2244215Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2244215
[CH:1]1[CH:2]=[CH:3][N:4]2[CH2:10][C:9]3[CH:11]=[CH:12][CH:13]=[CH:14][C:8]=3[NH:7][CH2:6][C:5]=12.CN(C)C1C=CC=CC=1.[C:24]1([C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)[CH:29]=[CH:28][C:27]([C:30](Cl)=[O:31])=[CH:26][CH:25]=1.O>O1CCOCC1>[C:24]1([C:33]2[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=2)[CH:25]=[CH:26][C:27]([C:30]([N:7]2[C:8]3[CH:14]=[CH:13][CH:12]=[CH:11][C:9]=3[CH2:10][N:4]3[CH:3]=[CH:2][CH:1]=[C:5]3[CH2:6]2)=[O:31])=[CH:28][CH:29]=1

Komponenten

6

Edukt 4

HCID 949N,N-DimethylanilineHCID 962WaterHCID 841514-Phenylbenzoyl chlorideHCID 1554704810,11-Dihydro-5H-benzo[e]pyrrolo[1,2-a][1,4]diazepine

Produkt 1

HCID 9799174HCID 9799174, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

To a solution of 5.53 g (0.03 mol) of 10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine in 50 mL of 1,4-dioxane was added 3.64 g (0.03 mol) of N,N-dimethylaniline followed by 6.50 g. of 4-biphenylcarbonyl chloride. The reaction solution was allowed to stand at room temperature for 2 hours and then slowly poured into 2 L of water. On cooling the mixture a crystalline white solid was formed which was collected and dried to provide the title compound (9.5 g). The product was used directly in the next step.

Aufarbeitung

  1. temperatureOn cooling the mixture a crystalline white solid
  2. customwas formed which
  3. customwas collected
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-9628790b887541ddb1efed3c326248f0
Quelldatensatz
uspto-grants-2010_03
Patentnummer
US07678787B2

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