Acetone → 2'-Methanesulfonyl-biphenyl-4-carboxylic acid

HRID 2244220Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2244220
CS[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[CH:14]=[CH:13][C:12]([C:15]([OH:17])=[O:16])=[CH:11][CH:10]=1.[CH3:18]C(C)=O.O[O:23][S:24]([O-:26])=O.[K+]>O>[CH3:18][S:24]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[CH:10]=[CH:11][C:12]([C:15]([OH:17])=[O:16])=[CH:13][CH:14]=1)(=[O:26])=[O:23]

Komponenten

5

Edukt 3

HCID 180AcetoneHCID 225963254-(2-Methylthiophenyl)benzoic acidHCID 23707502Potassium hydroxy sulfite

Produkt 1

HCID 225963472'-Methanesulfonyl-biphenyl-4-carboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

To a solution of 0.977 g (0.004 mole) of 2′-(methylthio)-1,1′-biphenyl-4-carboxylic acid of Example 14, Step A, in 25 mL of water and 75 mL of acetone was added 10 g. (0.163 mole) of oxone. The mixture was stirred overnight at room temperature. The acetone was removed in vacuo, and the residue was collected (0.80 g) and washed with water to provide a solid, m.p. 273-275° C.

Aufarbeitung

  1. customThe acetone was removed in vacuo
  2. customthe residue was collected (0.80 g)
  3. washwashed with water
  4. customto provide a solid, m.p. 273-275° C.

Quellen und Nachweise

ORD-Eintrag
ord-25c7964819074c458752cce0579da0af
Quelldatensatz
uspto-grants-2010_03
Patentnummer
US07678787B2

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