Hydrochloric Acid → HCID 11508375, Verbindung

HRID 2244416Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2244416
[CH3:1][C:2]1[S:3][C:4]([NH:21][C:22]2[CH:23]=[N:24][CH:25]=[CH:26][CH:27]=2)=[C:5]([C:7]([NH:9][C:10]2[N:15]=[C:14]([CH2:16][O:17]C(=O)C)[CH:13]=[CH:12][CH:11]=2)=[O:8])[N:6]=1.[OH-].[Na+].O.Cl>CO>[OH:17][CH2:16][C:14]1[N:15]=[C:10]([NH:9][C:7]([C:5]2[N:6]=[C:2]([CH3:1])[S:3][C:4]=2[NH:21][C:22]2[CH:23]=[N:24][CH:25]=[CH:26][CH:27]=2)=[O:8])[CH:11]=[CH:12][CH:13]=1

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14798Sodium HydroxideHCID 11560023HCID 11560023, Verbindung

Produkt 1

HCID 11508375HCID 11508375, VerbindungAusbeute 85,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of acetic acid 6-{[2-methyl-5-(pyridin-3-ylamino)-thiazole-4-carbonyl]-amino}-pyridin-2-ylmethyl ester (0.046 g, 0.12 mmol) in methanol (20.00 ml) was treated with a 2N solution of NaOH in water (1.00 ml, 2.00 mmol). After 15 min stirring at room temperature, the mixture was acidified with HCl 2N, and the solvents removed. The residue was purified by flash chromatography (dichloromethane/methanol) to yield the title compound (0.035 g, 85%) as a light yellow solid, MS (ISP): m/e=342.1 (M+H+).

Aufarbeitung

  1. customthe solvents removed
  2. customThe residue was purified by flash chromatography (dichloromethane/methanol)

Quellen und Nachweise

ORD-Eintrag
ord-f444a7d7c732431db19a2bd65588c207
Quelldatensatz
uspto-grants-2010_03
Patentnummer
US07678815B2

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