HCID 58674939, Verbindung → HCID 58674940, Verbindung

HRID 2244419Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2244419
[CH3:1][C:2]1[C:7]([O:8][C:9](=[O:11])[CH3:10])=[CH:6][CH:5]=[C:4]([N+:12]([O-])=O)[N:3]=1>C(O)C.[Pd]>[NH2:12][C:4]1[N:3]=[C:2]([CH3:1])[C:7]([O:8][C:9](=[O:11])[CH3:10])=[CH:6][CH:5]=1

Komponenten

4

Edukt 1

HCID 58674939HCID 58674939, Verbindung

Produkt 1

HCID 58674940HCID 58674940, VerbindungAusbeute 95 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

Acetic acid 2-methyl-6-nitro-pyridin-3-yl ester (0.30 g, 1.53 mmol) was dissolved in ethanol. 10% Pd/C (0.04 g, 0.38 mmol) was added, and the mixture was put under an atmosphere of hydrogen and stirred vigorously for 50 min at room temperature. The catalyst was filtered off, washing with ethanol, and the solvent removed under vacuum to yield acetic acid 6-amino-2-methyl-pyridin-3-yl ester (0.24 g, 95%) as a white solid, MS (ISP): m/e=166.2 (M+), which was used crude.

Aufarbeitung

  1. filtrationThe catalyst was filtered off
  2. washwashing with ethanol
  3. customthe solvent removed under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-197da1023afe4f79ba48c26dc27c8dcd
Quelldatensatz
uspto-grants-2010_03
Patentnummer
US07678815B2

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