Dextroamphetamine → 4-Methyl-N-(1-methyl-2-phenylethyl)benzenesulfonamide

HRID 224565

Reaktionsgleichung

Reaktionsgleichung von HRID 224565
[CH3:1][C@H:2]([NH2:10])[CH2:3][C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1.C(N(CC)CC)C.[C:18]1([CH3:28])[CH:23]=[CH:22][C:21]([S:24](Cl)(=[O:26])=[O:25])=[CH:20][CH:19]=1>C1C=CC=CC=1>[C:18]1([CH3:28])[CH:23]=[CH:22][C:21]([S:24]([NH:10][CH:2]([CH3:1])[CH2:3][C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=2)(=[O:26])=[O:25])=[CH:20][CH:19]=1

Komponenten

5

Edukt 3

HCID 5826DextroamphetamineHCID 73974-Toluenesulfonyl chlorideHCID 8471Triethylamine

Produkt 1

HCID 132498614-Methyl-N-(1-methyl-2-phenylethyl)benzenesulfonamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 241BenzeneLösungsmittel2×

Versuchsvorschrift

Dextro amphetamine (200 g) and triethylamine (164 g) were dissolved in 1500 ml. of benzene. A solution of p-toluene sulfonyl chloride (310g) in 500 ml. of benzene was added dropwise to the cooled solution during one hour. The reaction mixture was stirred for three hours at room temperature, then allowed to stand for approximately 16 hours (over night) at room temperature (approximately 20° C.). The salts were filtered off and the benzene solution was washed with dilute HCl, water and brine. Evaporation of the solvent afforded an oil.

Aufarbeitung

  1. waitto stand for approximately 16 hours
  2. customat room temperature
  3. custom(approximately 20° C.)
  4. filtrationThe salts were filtered off
  5. washthe benzene solution was washed with dilute HCl, water and brine
  6. customEvaporation of the solvent
  7. customafforded an oil

Quellen und Nachweise

ORD-Eintrag
ord-b403412b2678470f8919b8be94d0df2d
Quelldatensatz
uspto-grants-1980_11
Patentnummer
US04233217

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