6-Amino-3-methyl-5-nitroso-1-phenylpyrimidine-2,4(1H,3H)-dione → 5,6-Diamino-3-methyl-1-phenyluracil

HRID 224584Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 224584
[NH2:1][C:2]1[N:7]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[C:6](=[O:14])[N:5]([CH3:15])[C:4](=[O:16])[C:3]=1[N:17]=O>CN(C=O)C.O=[Pt]=O>[NH2:17][C:3]1[C:4](=[O:16])[N:5]([CH3:15])[C:6](=[O:14])[N:7]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[C:2]=1[NH2:1]

Komponenten

4

Edukt 1

HCID 127062666-Amino-3-methyl-5-nitroso-1-phenylpyrimidine-2,4(1H,3H)-dione

Produkt 1

HCID 110752755,6-Diamino-3-methyl-1-phenyluracil

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 345198Adams' catalystKatalysatorHCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

40.5 g of 6-amino-3-methyl-5-nitroso-1-phenyl-2,4-(1H, 3H)-pyrimidinedione (XVII) in 500 ml of DMF and in the presence of 0.3 g of PtO2 was the solution catalytically hydrogenated for 20 minutes at a pressure of 200 kPa. The reaction mixture was heated and the catalyst was filtered off. After cooling, crystals were filtered off and washed with DMF and water. Yield 21.4 g (XVIII). NMR

Aufarbeitung

  1. temperatureThe reaction mixture was heated
  2. filtrationthe catalyst was filtered off
  3. temperatureAfter cooling
  4. filtrationcrystals were filtered off
  5. washwashed with DMF and water

Quellen und Nachweise

ORD-Eintrag
ord-baedd3dcaa8d4d59add7c0c3ecd6ac79
Quelldatensatz
uspto-grants-1980_11
Patentnummer
US04233303

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