2-Chloro-3-methoxypyridine → 2,3-Dimethoxypyridine
Reaktionsgleichung
Cl[C:2]1[C:7]([O:8][CH3:9])=[CH:6][CH:5]=[CH:4][N:3]=1.[CH3:10][O-:11].[Na+]>CN(C)C=O>[CH3:10][O:11][C:2]1[C:7]([O:8][CH3:9])=[CH:6][CH:5]=[CH:4][N:3]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
The 2-chloro-3-methoxypyridine (2) (13 g, 90.6 mmol), from Step I, was stirred with 3-equivalents of sodium methoxide (14.7 g, 271.8 mmol) in dimethylformamide (100 mL) at 100° C. until completion of the reaction. The reaction mixture was then quenched with water and extracted with dichloromethane. The combined extracts were washed with water, concentrated and distilled (74° C.; 5 mm Hg) to give the product, 2,3-dimethoxypyridine (3), as a clear oil (7 g; 29% yield for two steps).
Aufarbeitung
- customThe reaction mixture was then quenched with water
- extractionextracted with dichloromethane
- washThe combined extracts were washed with water
- concentrationconcentrated
- distillationdistilled (74° C.; 5 mm Hg)
Quellen und Nachweise
- ORD-Eintrag
- ord-7fa384e2807d4d1789c437b8efa79210
- Quelldatensatz
- uspto-grants-2010_03
- Patentnummer
- US07687487B2
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