Hydroxylamine → 2-Fluoro-N'-hydroxy-4-(methanesulfonyl)benzene-1-carboximidamide
Reaktionsgleichung
[F:1][C:2]1[CH:9]=[C:8]([S:10]([CH3:13])(=[O:12])=[O:11])[CH:7]=[CH:6][C:3]=1[C:4]#[N:5].[NH2:14][OH:15]>C(O)C>[F:1][C:2]1[CH:9]=[C:8]([S:10]([CH3:13])(=[O:12])=[O:11])[CH:7]=[CH:6][C:3]=1[C:4](=[N:14][OH:15])[NH2:5]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 90 °C
Versuchsvorschrift
To a stirred solution of the product from Step E (0.29 g, 0.144 mmol) in ethanol (15 mL) was added hydroxylamine (50% in water, 3.0 mL). The reaction was heated at 90° C. for 3 h. The reaction was then concentrated to give the desired product.
Aufarbeitung
- concentrationThe reaction was then concentrated
Quellen und Nachweise
- ORD-Eintrag
- ord-c72f38cdac23496b9ee55ba9e6cbc827
- Quelldatensatz
- uspto-grants-2010_03
- Patentnummer
- US07687492B2
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