Water → 4-Aminocoumarin

HRID 224747

Reaktionsgleichung

Reaktionsgleichung von HRID 224747
O[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[O:5][C:4](=[O:12])[CH:3]=1.C([O-])(=O)C.[NH4+:17].O>C(O)CO>[NH2:17][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[O:5][C:4](=[O:12])[CH:3]=1

Komponenten

5

Edukt 3

HCID 962WaterHCID 517165Ammonium AcetateHCID 546829304-Hydroxycoumarin

Produkt 1

HCID 8208074-AminocoumarinAusbeute 99,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 174Ethylene GlycolLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

97.2 g of 4-hydroxycoumarin and 69.3 g of ammonium acetate in 300 ml of ethylene glycol are heated to 70° C. for 3 hours, whilst stirring, and to 160° C. for 6 hours, the mixture is cooled to 60° C., 1 liter of water is added, whilst stirring, and the mixture is cooled to room temperature. The colourless crystalline precipitate is filtered off, washed with water and dried in vacuo at 60° C. 96 g of 4-aminocoumarin in an almost pure form are obtained.

Aufarbeitung

  1. stirringwhilst stirring
  2. temperaturethe mixture is cooled to room temperature
  3. filtrationThe colourless crystalline precipitate is filtered off
  4. washwashed with water
  5. customdried in vacuo at 60° C

Quellen und Nachweise

ORD-Eintrag
ord-a991ef93bd7c452db36474033f77f721
Quelldatensatz
uspto-grants-1980_11
Patentnummer
US04234488

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