The crude product of the title compound was synthesized by conducting the reaction similar to that mentioned in Example 10 (10f) using 5-({[t-butyl(dimethyl)silyl]oxy}methyl)-N′-hydroxy-3-methylthiophene-2-carboximidamide (0.18 g, 0.60 mmol) that was obtained in Example 11 (11d), 3-fluoro-4-phenoxybenzoic acid (0.15 g, 0.66 mmol) that was obtained in Example 11 (11e), N,N′-dicyclohexylcarbodiimide (0.14 g, 0.66 mmol), and 1.0 M solution of tetrabutylammonium fluoride in tetrahydrofuran (0.90 mL, 0.90 mmol). Subsequently, the crude product of the title compound thus obtained was purified by chromatography on a silica gel column using a mixed solvent of ethyl acetate and hexane (1:1) as the eluent to afford the title compound (0.21 g) in a yield of 93% as a white crystalline solid.
