Acetic Acid → 1-({5-[5-(4-Isobutyl-3-methylphenyl)-1,2,4-oxadiazol-3-yl]pyridin-2-yl}methyl)azetidine-3-carboxylic acid

HRID 2247775Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2247775
[CH2:1]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[O:15][N:14]=[C:13]([C:16]3[CH:17]=[CH:18][C:19]([CH2:22][N:23]4[CH2:26][CH:25]([C:27]([O:29]C)=[O:28])[CH2:24]4)=[N:20][CH:21]=3)[N:12]=2)=[CH:7][C:6]=1[CH3:31])[CH:2]([CH3:4])[CH3:3].[OH-].[Na+].C(O)(=O)C.C(O)(=O)C(O)=O>>[CH2:1]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[O:15][N:14]=[C:13]([C:16]3[CH:17]=[CH:18][C:19]([CH2:22][N:23]4[CH2:26][CH:25]([C:27]([OH:29])=[O:28])[CH2:24]4)=[N:20][CH:21]=3)[N:12]=2)=[CH:7][C:6]=1[CH3:31])[CH:2]([CH3:4])[CH3:3]

Komponenten

5

Edukt 4

HCID 176Acetic AcidHCID 971Oxalic AcidHCID 14798Sodium HydroxideHCID 68528706Methyl 1-({5-[5-(4-isobutyl-3-methylphenyl)-1,2,4-oxadiazol-3-yl]pyridin-2-yl}methyl)azetidine-3-carboxylate

Produkt 1

HCID 119782791-({5-[5-(4-Isobutyl-3-methylphenyl)-1,2,4-oxadiazol-3-yl]pyridin-2-yl}methyl)azetidine-3-carboxylic acidAusbeute 94,1 %

Versuchsvorschrift

The title compound (0.13 g) was synthesized in a yield of 83% as a white crystalline solid by conducting the reaction similar to that mentioned in Example 21 (21d) using methyl 1-({5-[5-(4-isobutyl-3-methylphenyl)-1,2,4-oxadiazol-3-yl]pyridin-2-yl}methyl)azetidine-3-carboxylate (0.14 g, 0.34 mmol) that was obtained in Example 28 (28b), a 1 N aqueous solution of sodium hydroxide (11.0 mL, 1.0 mmol), acetic acid (58 μL, 1.0 mmol), and oxalic acid (15 mg, 0.17 mmol).

Aufarbeitung

  1. customthe reaction similar to

Quellen und Nachweise

ORD-Eintrag
ord-02d77bf39201461fb08359139d5261a8
Quelldatensatz
uspto-grants-2010_03
Patentnummer
US07687491B2

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