Dimethylformamide → (2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(fluoromethoxyimino)acetyl chloride
Reaktionsgleichung
[NH2:1][C:2]1[S:6][N:5]=[C:4](/[C:7](=[N:11]/[O:12][CH2:13][F:14])/[C:8](O)=[O:9])[N:3]=1.C(Cl)(=O)C([Cl:18])=O.CN(C)C=O>O1CCCC1>[NH2:1][C:2]1[S:6][N:5]=[C:4](/[C:7](=[N:11]/[O:12][CH2:13][F:14])/[C:8]([Cl:18])=[O:9])[N:3]=1Komponenten
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
In 30.0 ml of tetrahydrofuran (THF), 11.0 g of 2-(5-amino-1,2,4-thiadiazol-3-yl)-2(Z)-fluoromethoxyiminoacetic acid were stirred at -20° C., followed by the dropwise addition of a chlorinating reagent, which had been prepared beforehand by gradually adding 6.97 g of oxalyl chloride at 5° C. to a mixture of 80 ml of THF and 4.0 g of N,N-dimethylformamide (DMF) and then reacting them for 30 minutes. After they were reacted for 5 minutes, the reaction mixture was poured into 400 ml of ice water to precipitate crystals. The crystals were collected by filtration, washed with 100 ml of ice water, and then stirred for 30 minutes in 100 ml of n-hexane. After filtration, the resulting crystals were dried under reduced pressure, whereby the title compound was obtained. Yield: 6.70 g (56.3%). Purity: 91.5%.
Aufarbeitung
- additionfollowed by the dropwise addition of a chlorinating reagent, which
- customhad been prepared beforehand
- customfor 30 minutes
- customAfter they were reacted for 5 minutes
- customto precipitate crystals
- filtrationThe crystals were collected by filtration
- washwashed with 100 ml of ice water
- filtrationAfter filtration
- dry with materialthe resulting crystals were dried under reduced pressure, whereby the title compound
- customwas obtained
Quellen und Nachweise
- ORD-Eintrag
- ord-19ac882fec884d77b38654727510b7d9
- Quelldatensatz
- uspto-grants-1995_06
- Patentnummer
- US05428173
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