Hydrochloric Acid → 6,7-Difluoro-1-(4-fluorophenyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

HRID 2247928Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2247928
C([O:3][C:4]([C:6]1[C:15](=[O:16])[C:14]2[C:9](=[CH:10][C:11]([F:18])=[C:12]([F:17])[CH:13]=2)[N:8]([C:19]2[CH:24]=[CH:23][C:22]([F:25])=[CH:21][CH:20]=2)[CH:7]=1)=[O:5])C.Cl>C(O)(=O)C>[F:17][C:12]1[CH:13]=[C:14]2[C:9](=[CH:10][C:11]=1[F:18])[N:8]([C:19]1[CH:20]=[CH:21][C:22]([F:25])=[CH:23][CH:24]=1)[CH:7]=[C:6]([C:4]([OH:5])=[O:3])[C:15]2=[O:16]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 104728546,7-Difluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid ethyl ester

Produkt 1

HCID 104486226,7-Difluoro-1-(4-fluorophenyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acidAusbeute 86 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

6,7-Difluoro-1-(4-flurophenyl)-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid ethyl ester (14.5 g, 42 mmol) was mixed with acetic acid (300 ml), treated with 1N hydrochloric acid (100 ml) and heated to 100° for 4 hours. The reaction mixture was cooled and filtered, and the precipitate washed with water and ethyl ether to provide the title product as a solid, m.p. 252°-256° (11.5 g, 36.0 mmol, 86% yield).

Aufarbeitung

  1. temperatureheated to 100° for 4 hours
  2. temperatureThe reaction mixture was cooled
  3. filtrationfiltered
  4. washthe precipitate washed with water and ethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-45b1bd82eb27419cbad30be18a8b347b
Quelldatensatz
uspto-grants-1991_08
Patentnummer
US05037834

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