Ethanol → 2-(Acetoxyacetylamino)-6-aminobenzamide

HRID 2248763Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2248763
[C:1]([O:4][CH2:5][C:6]([NH:8][C:9]1[CH:16]=[CH:15][CH:14]=[C:13]([N+:17]([O-])=O)[C:10]=1[C:11]#[N:12])=[O:7])(=[O:3])[CH3:2].C1CCCCC=1.C([OH:28])C>[C].[Pd]>[C:1]([O:4][CH2:5][C:6]([NH:8][C:9]1[CH:16]=[CH:15][CH:14]=[C:13]([NH2:17])[C:10]=1[C:11]([NH2:12])=[O:28])=[O:7])(=[O:3])[CH3:2]

Komponenten

5

Edukt 3

HCID 702EthanolHCID 8079CyclohexeneHCID 149862822-(Acetoxyacetylamino)-6-nitrobenzonitrile

Produkt 1

HCID 149862792-(Acetoxyacetylamino)-6-aminobenzamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 178418390HCID 178418390, VerbindungKatalysator

Versuchsvorschrift

To a mixture of 2-(acetoxyacetylamino)-6-nitrobenzonitrile (5.7 g) and ethanol (50 ml) are added cyclohexene (10.5 ml) and 10% palladium-carbon (4.7 g). The mixture is refluxed for 20 minutes, and the reaction mixture is cooled to room temperature, and the solid materials are filtered off. The filtrate is distilled under reduced pressure. The residual crude crystals are recrystallized from ethanol to give the title compound (1.2 g) having the following physical properties.

Aufarbeitung

  1. temperatureThe mixture is refluxed for 20 minutes
  2. filtrationthe solid materials are filtered off
  3. distillationThe filtrate is distilled under reduced pressure
  4. customThe residual crude crystals are recrystallized from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-3ea07f62c85c475d8ad9dfedc7d035e2
Quelldatensatz
uspto-grants-1991_08
Patentnummer
US05041462

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