4-Bromo-2-nitroanisole → cis-3,5-Dimethyl-1-[4-(methyloxy)-3-nitrophenyl]piperazine

Temperatur

100 °C

To a solution of 4-bromo-1-methoxy-2-nitrobenzene (150 mg, 0.65 mmol) in dioxane (4 mL) was added (2R,6S)-2,6-dimethylpiperazine (221 mg, 1.94 mmol) followed by cesium carbonate (316 mg, 0.97 mmol), 2,2'-bis(diphenylphosphino)-1,1'-binaphthyl (56.4 mg, 0.09 mmol) and diacetoxypalladium (14.51 mg, 0.06 mmol). The resulting mixture was heated at 100 °C under argon over night (black). LCMS Ok. The solids were filtered through celite and washed with ethyl acetate. The ethyl acetate was evaporated under reduced pressure and the crude product was purified by flash- chromatograpy eluated with dichloromethane/ Methanol + 0.2% Et3N 100/0 =>90/10 over 20 min. The pure fractions was collected and concentrated to give (3R,5S)-1-(4-methoxy-3-nitrophenyl)-3,5-dimethylpiperazine (96 mg, 56.0 %) as red solid.

ORD-Eintrag

ord-fb5c3a40f09e4b5fab2cf5db4493aed4

Quelldatensatz

750 AstraZeneca ELN dataset

Originallink

Quelle ansehen