Ethylamine → HCID 59639667, Verbindung

HRID 2250090Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2250090
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9]3[CH:21]=[CH:20][C:19](=[O:22])[N:18]([C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=4[CH3:29])[C:10]=3[N:11]=[C:12](S(C)(=O)=O)[N:13]=2)=[C:4]([CH3:30])[CH:3]=1.[CH2:31]([NH2:33])[CH3:32]>>[CH2:31]([NH:33][C:12]1[N:13]=[C:8]([C:5]2[CH:6]=[CH:7][C:2]([F:1])=[CH:3][C:4]=2[CH3:30])[C:9]2[CH:21]=[CH:20][C:19](=[O:22])[N:18]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=3[CH3:29])[C:10]=2[N:11]=1)[CH3:32]

Komponenten

3

Edukt 2

HCID 6341EthylamineHCID 59639608HCID 59639608, Verbindung

Produkt 1

HCID 59639667HCID 59639667, VerbindungAusbeute 82,2 %

Versuchsvorschrift

Following the general procedure outlined in Example 126, the product of Example 121 (200 mg, 0.47 mmol), and ethylamine (1.18 mL, 2.36 mmol) were reacted to give the crude material. Purification by flash chromatography eluting with EtOAc/hexane/triethylamine (30/70/2, v/v/v), followed by recrystallization from dichloromethane and hexane, gave the desired product 150 mg (82%). LC-MS: 389.2 (MH+, m/z), 2.39 (Rt, min).

Aufarbeitung

  1. customto give the crude material
  2. customPurification by flash chromatography
  3. washeluting with EtOAc/hexane/triethylamine (30/70/2, v/v/v)
  4. customfollowed by recrystallization from dichloromethane and hexane

Quellen und Nachweise

ORD-Eintrag
ord-d230f9f6b688487387c3f12d8f45da6c
Quelldatensatz
uspto-grants-2008_01
Patentnummer
US07314934B2

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