Hydroxide → 4-({[(Benzyloxy)carbonyl]amino}sulfonyl)benzoic acid

HRID 2250560Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2250560
[CH2:1]([O:8][C:9]([NH:11][S:12]([C:15]1[CH:24]=[CH:23][C:18]([C:19]([O:21]C)=[O:20])=[CH:17][CH:16]=1)(=[O:14])=[O:13])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-]>CO>[CH2:1]([O:8][C:9]([NH:11][S:12]([C:15]1[CH:16]=[CH:17][C:18]([C:19]([OH:21])=[O:20])=[CH:23][CH:24]=1)(=[O:13])=[O:14])=[O:10])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Komponenten

4

Edukt 2

HCID 961HydroxideHCID 57444531Methyl 4-({[(benzyloxy)carbonyl]amino}sulfonyl)benzoate

Produkt 1

HCID 574445324-({[(Benzyloxy)carbonyl]amino}sulfonyl)benzoic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A suspension of methyl 4-({[(benzyloxy)carbonyl]amino}sulfonyl)benzoate (3.38 g) and 85% pottasium hydroxide (1.28 g) in methanol (40 mL) was stirred for 35 minutes. Methanol was evaporated off, and to the mixture was added 1N hydrochloric acid (20 mL). A white crystal was formed, which was collected by filtration and washed with water and diisopropyl ether, and dried under vacuum. 4-({[(Benzyloxy)carbonyl]amino}sulfonyl)benzoic acid was obtained as a white crystal (2.92 g).

Aufarbeitung

  1. customMethanol was evaporated off
  2. additionto the mixture was added 1N hydrochloric acid (20 mL)
  3. customA white crystal was formed
  4. filtrationwhich was collected by filtration
  5. washwashed with water and diisopropyl ether
  6. customdried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-6589a3b881c64dc1b36b6007a889f3f6
Quelldatensatz
uspto-grants-2008_01
Patentnummer
US07317009B2

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