2-(4-Nitro-3-pentafluorosulfanylphenyl)isoindole-1,3-dione → 2-(4-Amino-3-pentafluorosulfanylphenyl)isoindole-1,3-dione

HRID 2250849Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2250849
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[C:18](=[O:19])[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[C:11]2=[O:20])=[CH:6][C:5]=1[S:21]([F:26])([F:25])([F:24])([F:23])[F:22])([O-])=O.[H][H]>CO.[Pd]>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([N:10]2[C:18](=[O:19])[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[C:11]2=[O:20])=[CH:6][C:5]=1[S:21]([F:26])([F:25])([F:22])([F:23])[F:24]

Komponenten

5

Edukt 2

HCID 596421452-(4-Nitro-3-pentafluorosulfanylphenyl)isoindole-1,3-dioneHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 596421372-(4-Amino-3-pentafluorosulfanylphenyl)isoindole-1,3-dione

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

1.94 g (4.92 mmol) of 2-(4-nitro-3-pentafluorosulfanylphenyl)isoindole-1,3-dione (prepared in example 4) were dissolved in 20 ml of methanol, admixed with 10% palladium on activated carbon and hydrogenated at room temperature at a hydrogen pressure of 5 bar. On completion of reaction, the catalyst was filtered off and the filtrate concentrated. The residue was stirred in a mixture of dichloromethane and n-heptane, filtered with suction and dried under reduced pressure. 2-(4-amino-3-pentafluorosulfanylphenyl)isoindole-1,3-dione having a melting point of 176-178° C. was obtained.

Aufarbeitung

  1. customOn completion of reaction
  2. filtrationthe catalyst was filtered off
  3. concentrationthe filtrate concentrated
  4. filtrationfiltered with suction
  5. customdried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-d046372f43f249b1b3930eb03b145e13
Quelldatensatz
uspto-grants-2008_01
Patentnummer
US07317124B2

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