Hydrazine hydrate (1:1) → 4-(3-Dimethylaminopyrrolidin-1-yl)benzohydrazide

HRID 2251292Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2251292
[CH3:1][N:2]([CH3:19])[CH:3]1[CH2:7][CH2:6][N:5]([C:8]2[CH:18]=[CH:17][C:11]([C:12](OCC)=[O:13])=[CH:10][CH:9]=2)[CH2:4]1.O.[NH2:21][NH2:22]>C(O)C>[CH3:1][N:2]([CH3:19])[CH:3]1[CH2:7][CH2:6][N:5]([C:8]2[CH:18]=[CH:17][C:11]([C:12]([NH:21][NH2:22])=[O:13])=[CH:10][CH:9]=2)[CH2:4]1

Komponenten

4

Edukt 2

HCID 24654Hydrazine hydrate (1:1)HCID 69209289Ethyl 4-(3-dimethylaminopyrrolidin-1-yl)benzoate

Produkt 1

HCID 692131084-(3-Dimethylaminopyrrolidin-1-yl)benzohydrazide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
5 °C

Versuchsvorschrift

A mixture of ethyl 4-(3-dimethylaminopyrrolidin-1-yl)benzoate (2.0 g), hydrazine hydrate (3.8 g) and ethanol (7 ml) was boiled under reflux for 15 hours. After cooling to 5° C., the resulting precipitate was filtered off with suction. The product with the molecular weight of 248.33 (C13H20N4O) was obtained in this way; MS (ESI): 249 (M+H+).

Aufarbeitung

  1. temperatureunder reflux for 15 hours
  2. filtrationthe resulting precipitate was filtered off with suction
  3. customThe product with the molecular weight of 248.33 (C13H20N4O) was obtained in this way

Quellen und Nachweise

ORD-Eintrag
ord-13da222b8a284726b4e6314b1c964c5d
Quelldatensatz
uspto-grants-2008_01
Patentnummer
US07319108B2

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