Water → 3-Methyl-3-azabicyclo[3.1.0]hexane-1-carboxylic acid

Reaktionsgleichung

[CH3:1][N:2]1[CH2:7][CH:6]2[C:4]([C:8]#N)([CH2:5]2)[CH2:3]1.[OH-:10].[K+].[OH2:12]>>[CH3:1][N:2]1[CH2:7][CH:6]2[C:4]([C:8]([OH:12])=[O:10])([CH2:5]2)[CH2:3]1

Komponenten

Edukt 3

HCID 962Water

HCID 14797Potassium Hydroxide

HCID 121996863-Methyl-3-azabicyclo[3.1.0]-hexane-1-carbonitrile

Produkt 1

HCID 233291843-Methyl-3-azabicyclo[3.1.0]hexane-1-carboxylic acid

Versuchsvorschrift

A solution of 10 g of 3-methyl-3-azabicyclo[3.1.0]-hexane-1-carbonitrile is 60 ml of saturated ethanolic KOH and 20 ml of water is boiled under reflux for 15 hours. After neutralization with hydrochloric acid the mixture is evaporated and the title compound is extracted from the resultant dried residue with hot absolute ethanol (M.P. 193°-195°).

Aufarbeitung

temperatureunder reflux for 15 hours
customAfter neutralization with hydrochloric acid the mixture is evaporated
extractionthe title compound is extracted from the resultant dried residue with hot absolute ethanol (M.P. 193°-195°)

Quellen und Nachweise

ORD-Eintrag: ord-1f7c16e7d879450b9f9cf03cf27fb9d0
Quelldatensatz: uspto-grants-1980_11
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US04235921

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