Bromine → 1,2-Benzenediol, 3-bromo-5-(trifluoromethyl)-

HRID 2251606Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2251606
[F:1][C:2]([F:12])([F:11])[C:3]1[CH:4]=[C:5]([OH:10])[C:6]([OH:9])=[CH:7][CH:8]=1.[Br:13]Br>C(Cl)(Cl)(Cl)Cl>[Br:13][C:7]1[CH:8]=[C:3]([C:2]([F:11])([F:12])[F:1])[CH:4]=[C:5]([OH:10])[C:6]=1[OH:9]

Komponenten

4

Edukt 2

HCID 24408BromineHCID 120404464-(Trifluoromethyl)benzene-1,2-diol

Produkt 1

HCID 596430371,2-Benzenediol, 3-bromo-5-(trifluoromethyl)-

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 5943Carbon TetrachlorideLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

To a solution of 4-trifluoromethyl-benzene-1,2-diol (870 mg, 4.8 mmol) in 20 mL CCl4, Br2 (770 mg, 4.8 mmol, 1 eq.) was added and the mixture was stirred at 60° C. for 10 h. The sol-vent was then removed in vacuo and the crude product was purified by flash chromatography (silica gel, hexane/EtOAc 4:1→3:2) to yield the desired product as a yellowish oil.

Aufarbeitung

  1. customThe sol-vent was then removed in vacuo
  2. customthe crude product was purified by flash chromatography (silica gel, hexane/EtOAc 4:1→3:2)

Quellen und Nachweise

ORD-Eintrag
ord-b1166a003aa942bf91dda6dbd345de0d
Quelldatensatz
uspto-grants-2008_01
Patentnummer
US07319101B2

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