3-Dimethylamino-3'-trifluoromethylacrylophenone → 2-Methyl-7-(alpha,alpha,alpha-trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile

HRID 225238

Reaktionsgleichung

Reaktionsgleichung von HRID 225238
C[N:2]([CH3:17])[CH:3]=[CH:4][C:5]([C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([C:13]([F:16])([F:15])[F:14])[CH:8]=1)=O.[CH3:18][C:19]1[C:23](C#N)=[C:22]([NH2:26])[NH:21][N:20]=1>C(O)(=O)C>[CH3:18][C:19]1[C:23]([C:22]#[N:26])=[C:17]2[N:2]=[CH:3][CH:4]=[C:5]([C:7]3[CH:8]=[C:9]([C:13]([F:14])([F:15])[F:16])[CH:10]=[CH:11][CH:12]=3)[N:21]2[N:20]=1

Komponenten

4

Edukt 2

HCID 7300243-Dimethylamino-3'-trifluoromethylacrylophenoneHCID 178434678HCID 178434678, Verbindung

Produkt 1

HCID 150420842-Methyl-7-(alpha,alpha,alpha-trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

A mixture of 24.3 g. of 3-dimethylamino-3'-(trifluoromethyl)acrylophenone, 150 ml. of glacial acetic acid and 12.2 g. of 3-methyl-5-aminopyrazole-4-carbonitrile is refluxed for 6 hours and then evaporated. The residue is treated as described in Example 1, giving the desired product, m.p. 149°-150° C.

Aufarbeitung

  1. additionA mixture of 24.3 g
  2. customevaporated
  3. additionThe residue is treated

Quellen und Nachweise

ORD-Eintrag
ord-7e4cf7ca5cff4ce0be2a6e84e95206d3
Quelldatensatz
uspto-grants-1980_11
Patentnummer
US04236005

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