3',4'-Dimethyl-3-dimethylaminoacrylophenone → Ethyl 7-(3,4-dimethylphenyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate

HRID 225284

Reaktionsgleichung

Reaktionsgleichung von HRID 225284
[CH3:1][C:2]1[CH:3]=[C:4]([C:9](=O)[CH:10]=[CH:11][N:12]([CH3:14])C)[CH:5]=[CH:6][C:7]=1[CH3:8].N[C:17]1[C:21]([C:22]([O:24][CH2:25][CH3:26])=[O:23])=C[NH:19][N:18]=1>C(O)(=O)C>[C:4]1([C:9]2[N:19]3[N:18]=[CH:17][C:21]([C:22]([O:24][CH2:25][CH3:26])=[O:23])=[C:14]3[N:12]=[CH:11][CH:10]=2)[CH:5]=[CH:6][C:7]([CH3:8])=[C:2]([CH3:1])[CH:3]=1

Komponenten

4

Edukt 2

HCID 543118443',4'-Dimethyl-3-dimethylaminoacrylophenoneHCID 178469928HCID 178469928, Verbindung

Produkt 1

HCID 11346960Ethyl 7-(3,4-dimethylphenyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

A mixture of 4.06 g. of 3',4'-dimethyl-3-dimethylaminoacrylophenone and 3.10 g. of ethyl 3-aminopyrazole-4-carboxylate in 25 ml. of glacial acetic acid is refluxed for 6 hours. The desired compound is recovered as in previous examples except that the compound as first observed is amorphous and then crystallizes on standing in the crystallization solvent, m.p. 187°-188° C.

Aufarbeitung

  1. additionA mixture of 4.06 g

Quellen und Nachweise

ORD-Eintrag
ord-62e38a1efe7b44b5b4f7de60b49e8639
Quelldatensatz
uspto-grants-1980_11
Patentnummer
US04236005

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