Hydrochloric Acid → HCID 9944111, Verbindung

HRID 2253350Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2253350
[BH4-].[Na+].[CH3:3][C:4]([O:15][C:16]1[CH:21]=[C:20]([CH3:22])[CH:19]=[C:18]([CH3:23])[C:17]=1[CH3:24])([CH3:14])[C:5]([C:7]1[CH:12]=[CH:11][C:10]([CH3:13])=[CH:9][CH:8]=1)=[O:6].Cl>[OH-].[Na+].CO>[CH3:14][C:4]([O:15][C:16]1[CH:21]=[C:20]([CH3:22])[CH:19]=[C:18]([CH3:23])[C:17]=1[CH3:24])([CH3:3])[CH:5]([C:7]1[CH:8]=[CH:9][C:10]([CH3:13])=[CH:11][CH:12]=1)[OH:6]

Komponenten

6

Edukt 3

HCID 313Hydrochloric AcidHCID 4311764Sodium borohydrideHCID 9879261HCID 9879261, Verbindung

Produkt 1

HCID 9944111HCID 9944111, VerbindungAusbeute 100 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 14798Sodium HydroxideLösungsmittel

Reaktionsbedingungen

Temperatur
35 °C

Versuchsvorschrift

A solution of sodium borohydride (25.7 g) in 0.1N NaOH (202 mL) was added dropwise to a suspension of 2-methyl-1-(4-methylphenyl)-2-(2,3,5-trimethylphenoxy)-1-propanone (251.9 g) in methanol (2519 mL). The mixture was stirred at 35° C. for 3 hours. After the mixture was adjusted to pH 7 by addition of 1N HCl under ice-cooling, methanol was distilled off, followed by extraction with toluene (2015 mL). The extract was washed, and the solvent was distilled off to quantitatively obtain the title compound as an oil (253.7 g).

Aufarbeitung

  1. temperaturecooling
  2. distillationmethanol was distilled off
  3. extractionfollowed by extraction with toluene (2015 mL)
  4. washThe extract was washed
  5. distillationthe solvent was distilled off

Quellen und Nachweise

ORD-Eintrag
ord-b02c06dabc7e4312a821568f664a0689
Quelldatensatz
uspto-grants-2008_01
Patentnummer
US07323577B2

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