Sodium Iodide → (E)-1-Iodo-1-octen-3-one
Reaktionsgleichung
[I-:1].[Na+].Cl/[CH:4]=[CH:5]/[C:6](=[O:12])[CH2:7][CH2:8][CH2:9][CH2:10][CH3:11]>CC(C)=O>[I:1]/[CH:4]=[CH:5]/[C:6](=[O:12])[CH2:7][CH2:8][CH2:9][CH2:10][CH3:11]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
A mixture of 54.5 g. (0.364 mole) of sodium iodide and 40 g. (0.249 mole) of 1-chloro-trans-1-octen-3-one (Example 222) in 360 ml. of acetone is stirred and refluxed for 24 hours. The reaction mixture is cooled, filtered and concentrated. The residue is partitioned between water and ether. The organic phase is washed with dilute sodium bicarbonate solution, brine, dried (MgSO4) and evaporated to an oil. This material is used directly without purification.
Aufarbeitung
- additionA mixture of 54.5 g
- temperaturerefluxed for 24 hours
- temperatureThe reaction mixture is cooled
- filtrationfiltered
- concentrationconcentrated
- customThe residue is partitioned between water and ether
- washThe organic phase is washed with dilute sodium bicarbonate solution, brine
- dry with materialdried (MgSO4)
- customevaporated to an oil
- customThis material is used directly without purification
Quellen und Nachweise
- ORD-Eintrag
- ord-e3cdc0a197cb4b82be7bab39af496ffe
- Quelldatensatz
- uspto-grants-1980_11
- Patentnummer
- US04236027
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