Methyl iodide → HCID 15733061, Verbindung

HRID 2255408Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2255408
[CH3:1]I.[Mg].[Cl-].[C:5]1([CH2:11][N+:12]2[CH:17]=[CH:16][C:15]([CH3:18])=[C:14]([CH3:19])[CH:13]=2)[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.[Cl-].[NH4+]>CCOCC>[C:5]1([CH2:11][N:12]2[CH:17]=[CH:16][C:15]([CH3:18])=[C:14]([CH3:19])[CH:13]2[CH3:1])[CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=1

Komponenten

6

Edukt 4

HCID 6328Methyl iodideHCID 25517Ammonium ChlorideHCID 5462224MagnesiumHCID 139786171-Benzyl-3,4-dimethylpyridin-1-ium chloride

Produkt 1

HCID 15733061HCID 15733061, VerbindungAusbeute 88,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel3×

Versuchsvorschrift

A solution of methyl iodide (112 mL, 1.8 mole) in ether (225 mL) was added dropwise to a suspension of magnesium turnings (44 g, 1.8 mole) in ether (225 mL) under nitrogen over a period of 1 hour. The mixture was stirred at room temperature for 1 hour, transferred into a 1000 mL addition funnel and then was added to a suspension of N-(phenylmethyl)-3,4-dimethylpyridinium chloride (350.7 g, 1.5 mole) in ether (1500 mL) under a nitrogen atmosphere. The reaction mixture was stirred at room temperature for 24 hours and was then poured into a solution of saturated ammonium chloride (3 L). The organic layer was separated and the aqueous layer was extracted with ether (1000 mL). The combined ether layers were washed with water (500 mL), then brine (500 mL) and were dried over sodium sulfate and potassium carbonate. The solvent was removed in vacuo to afford 284.1 g (76%) of 1,2-dihydro-N-(phenylmethyl)-2,3,4-trimethylpyridine as an amber oil.

Aufarbeitung

  1. additiontransferred into a 1000 mL addition funnel
  2. stirringThe reaction mixture was stirred at room temperature for 24 hours
  3. customThe organic layer was separated
  4. extractionthe aqueous layer was extracted with ether (1000 mL)
  5. washThe combined ether layers were washed with water (500 mL)
  6. dry with materialbrine (500 mL) and were dried over sodium sulfate and potassium carbonate
  7. customThe solvent was removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-8c70c22d758444418b5eb4da7a42026c
Quelldatensatz
uspto-grants-1993_08
Patentnummer
US05240935

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