Isopropylamine → Isopropylammonium 3-methyl-5-isothiazolecarboxylate

HRID 2255490Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2255490
[CH3:1][C:2]1[CH:6]=[C:5]([C:7]([OH:9])=[O:8])[S:4][N:3]=1.[CH:10]([NH2:13])([CH3:12])[CH3:11]>O1CCCC1>[CH3:1][C:2]1[CH:6]=[C:5]([C:7]([O-:9])=[O:8])[S:4][N:3]=1.[CH:10]([NH3+:13])([CH3:12])[CH3:11]

Komponenten

4

Edukt 2

HCID 6363IsopropylamineHCID 2740923-Methyl-1,2-thiazole-5-carboxylic acid

Produkt 1

HCID 19738253Isopropylammonium 3-methyl-5-isothiazolecarboxylateAusbeute 85,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel2×

Versuchsvorschrift

3-Methyl-5-isothiazolecarboxylic acid (1.0 g) was dissolved in 10 ml of dry tetrahydrofuran, in which a solution of 0.41 g of isopropylamine in 5 ml of dry tetrahydrofuran were added dropwise at room temperature under stirring. White crystals were formed concurrently with the dropwise addition. After the reaction mixture was stirred further at room temperature for 30 minutes, crystals were collected by filtration and washed with a small amount of dry tetrahydrofuran. The crystals were dried at 40° C. for 3 hours under reduced pressure, whereby 1.20 g of the title compound were obtained (yield: 85%).

Aufarbeitung

  1. additionwere added dropwise at room temperature
  2. customWhite crystals were formed concurrently with the dropwise addition
  3. stirringAfter the reaction mixture was stirred further at room temperature for 30 minutes
  4. filtrationcrystals were collected by filtration
  5. washwashed with a small amount of dry tetrahydrofuran
  6. customThe crystals were dried at 40° C. for 3 hours under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-f0a0db6f45a5443492cc50a77ba0e767
Quelldatensatz
uspto-grants-1993_08
Patentnummer
US05240951

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