Hydrochloric Acid → 5-Chloro-2,3-dimethyl-2,7-diazabicyclo[3.3.0]octane

HRID 2255705Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2255705
[Cl:1][C:2]12[CH2:9][N:8](C(OCC)=O)[CH2:7][CH:6]1[N:5]([CH3:15])[CH:4]([CH3:16])[CH2:3]2.Cl.C(=O)([O-])[O-].[K+].[K+]>O>[Cl:1][C:2]12[CH2:9][NH:8][CH2:7][CH:6]1[N:5]([CH3:15])[CH:4]([CH3:16])[CH2:3]2

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 11430Potassium CarbonateHCID 19100959HCID 19100959, Verbindung

Produkt 1

HCID 191009535-Chloro-2,3-dimethyl-2,7-diazabicyclo[3.3.0]octane

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

7.6 g (30.8 mmol) of ethyl 5-chloro-2,3-dimethyl-2,7-diazabicyclo[3.3.01octane-7-carboxylate are heated under reflux overnight with 30 ml of concentrated hydrochloric acid. The mixture ic concentrated, the residue is taken up in 30 ml of water, and the mixture is rendered alkaline with potassium carbonate, extracted five times with 50 ml of chloroform each time, dried over potassium carbonate and concentrated, and the residue is distilled.

Aufarbeitung

  1. extractionextracted five times with 50 ml of chloroform each time
  2. dry with materialdried over potassium carbonate
  3. concentrationconcentrated
  4. distillationthe residue is distilled

Quellen und Nachweise

ORD-Eintrag
ord-830de90d22b94c4091e4e4af99ec72f3
Quelldatensatz
uspto-grants-1993_08
Patentnummer
US05241076

Notizen zur Reaktion

Wird geladen…